Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression

• DOI: 10.1038/ncomms10195
• Publication Date: 2015-12-16T11:45:16Z
• Authors: Alejandro Lomniczi; Hollis Wright; Juan Manuel Caste...; Valerie Matagne; Carlos A. Toro; Suresh Ramaswamy; Tony M. Plant; Sergio R. Ojeda
• Keywords: Demethylase

Abstract In primates, puberty is unleashed by increased GnRH release from the hypothalamus following an interval of juvenile quiescence. GWAS implicates Zinc finger ( ZNF ) genes in timing human puberty. Here we show that hypothalamic expression several s decreased agonadal male monkeys association with pubertal reactivation gonadotropin secretion. Expression two these s, GATAD1 and ZNF573 , also decreases peripubertal female monkeys. However, only abundance increases when secretion suppressed during late infancy. Targeted delivery or to rat delays impairing transition a transcriptional network immature repressive epigenetic configuration one activation. represses transcription key puberty-related genes, KISS1 TAC3 directly, reduces activating histone mark H3K4me2 at each promoter via recruitment demethylase KDM1A. We conclude epitomizes subset ZNFs involved repression primate