Pten and EphB4 regulate the establishment of perisomatic inhibition in mouse visual cortex

• DOI: 10.1038/ncomms12829
• Publication Date: 2016-09-09T14:35:36Z
• Authors: Amy Baohan; Taruna Ikrar; Elaine Tring; Xiangmin Xu; Joshua T. Trachte...
• Keywords: 0301 basic medicine; Light; Science; Receptor, EphB4; Article; Mice; 03 medical and health sciences; 2.1 Biological and endogenous factors; Animals; Aetiology; Visual Cortex; Neurons; Biomedical and Clinical Sciences; Mammalian; Pyramidal Cells; Q; Neurosciences; PTEN Phosphohydrolase; EphB4; Embryo, Mammalian; Brain Disorders; Parvalbumins; Gene Expression Regulation; Embryo; Neurological; Mutation; Gene Deletion; Receptor; Signal Transduction

Perisomatic inhibition of pyramidal neurons is established by fast-spiking, parvalbumin-expressing interneurons (PV cells). Failure to assemble adequate perisomatic thought underlie the aetiology neurological dysfunction in seizures, autism spectrum disorders and schizophrenia. Here we show that mouse visual cortex, strong does not develop if PV cells lack a single copy Pten. PTEN signalling appears drive assembly an experience-dependent manner suppressing expression EphB4; hemizygous for Pten ∼2-fold increase EphB4, over-expression EphB4 adult causes dismantling inhibition. These findings implicate molecular disinhibitory mechanism driving establishment whereby experience enhances signalling, resulting suppression expression; this relieves native synaptic repulsion between neurons, thereby promoting