Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

• DOI: 10.1038/ncomms1285
• Publication Date: 2011-04-19T09:07:09Z
• Authors: María Mittelbrunn; Cristina Gutiérre...; Carolina Villarro...; Susana González; Fátima Sánchez-Cabo; Manuel Ángel Gonz...; Antonio Bernad; Francisco Sánchez...
• Keywords: Immunological synapse; Exosome

The immune synapse is an exquisitely evolved means of communication between T cells and antigen-presenting (APCs) during antigen recognition. Recent evidence points to the transfer RNA via exosomes as a novel mode intercellular communication. Here we show that T, B dendritic contain microRNA (miRNA) repertoires differ from those their parent cells. We investigate whether miRNAs are exchanged cognate interactions, demonstrate existence antigen-driven unidirectional cell APC, mediated by delivery CD63+ on formation. Inhibition exosome production targeting neutral sphingomyelinase-2 impairs APCs. Moreover, transferred synapsis able modulate gene expression in recipient Thus, our results support mechanism cellular involving antigen-dependent, synapsis. Exosomes released can In this study, authors microRNAs be synapsis, alter expression, suggesting new form