UVR2 ensures transgenerational genome stability under simulated natural UV-B in Arabidopsis t haliana

• DOI: 10.1038/ncomms13522
• Publication Date: 2016-12-01T10:09:07Z
• Authors: Eva-Maria Willing; Thomas Piofczyk; Andreas Albert; J. Barbro Winkler; Korbinian Schneeb...; Ales Pecinka
• Keywords: Pyrimidine dimer; Wild type

Abstract Ground levels of solar UV-B radiation induce DNA damage. Sessile phototrophic organisms such as vascular plants are recurrently exposed to sunlight and require photoreception, flavonols shielding, direct reversal pyrimidine dimers nucleotide excision repair for resistance against radiation. However, the frequency UV-B-induced mutations is unknown in plants. Here we quantify amount types offspring Arabidopsis thaliana wild-type UV-B-hypersensitive mutants simulated natural over their entire life cycle. We show that by UVR2 photolyase major mechanism required sustaining plant genome stability across generations under UV-B. In addition widespread somatic expression, germline-specific activity occurs during late flower development, important ensuring low mutation rates male female cell lineages. This allows maintain integrity germline despite exposure