Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

• DOI: 10.1038/ncomms7760
• Publication Date: 2015-05-19T15:23:39Z
• Authors: Scott Ayton; Noel G. Faux; Ashley I. Bush; ; Michael W. Weiner; Paul Aisen; Ronald Petersen; Clifford R. Jack; William Jagust; John Q. Trojanowki; Arthur W. Toga; Laurel Beckett; Robert C. Green; Andrew J. Saykin; John Morris; Leslie M. Shaw; Zaven Khachaturian; Greg Sorensen; Lew Kuller; Marc Raichle; Steven Paul; Peter Davies; Howard Fillit; Franz Hefti; Davie Holtzman; M. Marcel Mesulam; William Potter; Peter Snyder; Adam Schwartz; Tom Montine; Ronald G. Thomas; Michael Donohue; Sarah Walter; Devon Gessert; Tamie Sather; Gus Jiminez; Danielle Harvey; Matthew Bernstein; Nick Fox; Paul Thompson; Norbert Schuff; Bret Borowski; Jeff Gunter; Matt Senjem; Prashanthi Vemuri; David Jones; Kejal Kantarci; Chad Ward; Robert A. Koeppe; Norm Foster; Eric M. Reiman; Kewei Chen; Chet Mathis; Susan Landau; Nigel J. Cairns; Erin Householder; Lisa Taylor-Reinwald; Virginia Lee; Magdalena Korecka; Michal Figurski; Karen Crawford; Scott Neu; Tatiana M. Foroud; Steven Potkin; Li Shen; Kelley Faber; Sungeun Kim; Kwangsik Nho; Leon Thal; Neil Buckholtz; Marylyn Albert; Richard Frank; John Hsiao; Jeffrey Kaye; Joseph Quinn; Betty Lind; Raina Carter; Sara Dolen; Lon S. Schneider; Sonia Pawluczyk; Mauricio Beccera; Liberty Teodoro; Bryan M. Spann; James Brewer; Helen Vanderswag; Adam Fleisher; Judith L. Heidebrink; Joanne L. Lord; Sara S. Mason; Colleen S. Albers; David Knopman; Kris Johnson; Rachelle S. Doody; Javier Villanueva...; Munir Chowdhury; Susan Rountree; Mimi Dang; Yaakov Stern; Lawrence S. Honig; Karen L. Bell; Beau Ances; Maria Carroll; Sue Leon; Mark A. Mintun; Stacy Schneider; Angela Oliver; Daniel Marson; Randall Griffith; David Clark; David Geldmacher; John Brockington; Erik Roberson; Hillel Grossman; Effie Mitsis; Leyla deToledo-Mo...; Raj C. Shah; Ranjan Duara; Daniel Varon; Maria T. Greig; Peggy Roberts; Marilyn Albert; Chiadi Onyike; Daniel D’Agostino II; Stephanie Kielb; James E. Galvin; Brittany Cerbone; Christina A. Michel; Henry Rusinek; Mony J de Leon; Lidia Glodzik; Susan De Santi; P. Murali Doraiswamy; Jeffrey R. Petrella; Terence Z. Wong; Steven E. Arnold; Jason H. Karlawish; David Wolk; Charles D. Smith; Greg Jicha; Peter Hardy; Partha Sinha; Elizabeth Oates; Gary Conrad; Oscar L. Lopez; MaryAnn Oakley; Donna M. Simpson; Anton P. Porstein...; Bonnie S. Goldstein; Kim Martin; Kelly M. Makino; M. Saleem Ismail; Connie Brand; Ruth A. Mulnard; Gaby Thai; Catherine Mc-Adam...; Kyle Womack; Dana Mathews; Mary Quiceno; Ramon Diaz-Arrastia; Richard King; Myron Weiner; Kristen Martin-Cook; Michael DeVous; Allan I. Levey; James J. Lah; Janet S. Cellar; Jeffrey M. Burns; Heather S. Anderson; Russell H. Swerdlow; Liana Apostolova; Kathleen Tingus; Ellen Woo; Daniel H.S. Silve...; Po H. Lu; George Bartzokis; Neill R Graff-Rad...; Francine Parfitt; Tracy Kendall; Heather Johnson; Martin R. Farlow; Ann Marie Hake; Brandy R. Matthews; Scott Herring; Cynthia Hunt; Christopher H. va...; Richard E. Carson; Martha G. MacAvoy; Howard Chertkow; Howard Bergman; Chris Hosein; Sandra Black; Bojana Stefanovic; Curtis Caldwell; Ging-Yuek Robin H...; Howard Feldman; Benita Mudge; Michele Assaly; Andrew Kertesz; John Rogers; Charles Bernick; Donna Munic; Diana Kerwin; Marek-Marsel Mesulam; Kristine Lipowski; Chuang-Kuo Wu; Nancy Johnson; Carl Sadowsky; Walter Martinez; Teresa Villena; Raymond Scott Turner; Kathleen Johnson; Brigid Reynolds; Reisa A. Sperling; Keith A. Johnson; Gad Marshall; Meghan Frey; Barton Lane; Allyson Rosen; Jared Tinklenberg; Marwan N. Sabbagh; Christine M. Belden; Sandra A. Jacobson; Sherye A. Sirrel; Neil Kowall; Ronald Killiany; Andrew E. Budson; Alexander Norbash; Patricia Lynn Joh...; Joanne Allard; Alan Lerner; Paula Ogrocki; Leon Hudson; Evan Fletcher; Owen Carmichael; John Olichney; Charles DeCarli; Smita Kittur; Michael Borrie; T-Y Lee; Rob Bartha; Sterling Johnson; Sanjay Asthana; Cynthia M. Carlsson; Steven G. Potkin; Adrian Preda; Dana Nguyen; Pierre Tariot; Stephanie Reeder; Vernice Bates; Horacio Capote; Michelle Rainka; Douglas W. Scharre; Maria Kataki; Anahita Adeli; Earl A. Zimmerman; Dzintra Celmins; Alice D. Brown; Godfrey D. Pearlson; Karen Blank; Karen Anderson; Robert B. Santulli; Tamar J. Kitzmiller; Eben S. Schwartz; Kaycee M. Sink; Jeff D. Williamson; Pradeep Garg; Franklin Watkins; Brian R. Ott; Henry Querfurth; Geoffrey Tremont; Stephen Salloway; Paul Malloy; Stephen Correia; Howard J. Rosen; Bruce L. Miller; Jacobo Mintzer; Kenneth Spicer; David Bachman; Elizabether Finger; Stephen Pasternak; Irina Rachinsky; Dick Drost; Nunzio Pomara; Raymundo Hernando; Antero Sarrael; Susan K. Schultz; Laura L. Boles Ponto; Hyungsub Shim; Karen Elizabeth S...; Norman Relkin; Gloria Chaing; Lisa Raudin; Amanda Smith; Kristin Fargher; Balebail Ashok Raj; Thomas Neylan; Jordan Grafman; Melissa Davis; Rosemary Morrison; Jacqueline Hayes; Shannon Finley; Karl Friedl; Debra Fleischman; Konstantinos Arfa...; Olga James; Dino Massoglia; J. Jay Fruehling; Sandra Harding; Elaine R. Peskind; Eric C. Petrie; Gail Li; Jerome A. Yesavage; Joy L. Taylor; Ansgar J. Furst
• Keywords: Apolipoprotein E

Abstract Brain iron elevation is implicated in Alzheimer’s disease (AD) pathogenesis, but the impact of on outcomes has not been previously explored a longitudinal study. Ferritin major storage protein body; by using cerebrospinal fluid (CSF) levels ferritin as an index, we whether brain status impacts Disease Neuroimaging Initiative (ADNI) cohort. We show that baseline CSF were negatively associated with cognitive performance over 7 years 91 cognitively normal, 144 mild impairment (MCI) and 67 AD subjects, predicted MCI conversion to AD. was strongly apolipoprotein E elevated risk allele, APOE-ɛ4 . These findings reveal adversely progression, introduce possible mechanism for being genetic factor