Large-scale genomics unveil polygenic architecture of human cortical surface area

• DOI: 10.1038/ncomms8549
• Publication Date: 2015-07-20T09:18:39Z
• Authors: Chi-Hua Chen; Qian Peng; Andrew J. Schork; Min-Tzu Lo; Chun-Chieh Fan; Yunpeng Wang; Rahul S. Desikan; Francesco Bettella; Donald J. Hagler; ; Connor McCabe; Linda Chang; Natacha Akshoomoff; Erik Newman; Thomas Ernst; Peter Van Zijl; Joshua Kuperman; Sarah Murray; Cinnamon Bloss; Mark Appelbaum; Anthony Gamst; Wesley Thompson; Hauke Bartsch; ; Michael Weiner; Paul Aisen; Ronald Petersen; Clifford R. Jack Jr; William Jagust; John Q. Trojanowki; Arthur W. Toga; Laurel Beckett; Robert C. Green; Andrew J. Saykin; John Morris; Leslie M. Shaw; Zaven Khachaturian; Greg Sorensen; Maria Carrillo; Lew Kuller; Marc Raichle; Steven Paul; Peter Davies; Howard Fillit; Franz Hefti; Davie Holtzman; M. Marcel Mesulman; William Potter; Peter J. Snyder; Adam Schwartz; Tom Montine; Ronald G. Thomas; Michael Donohue; Sarah Walter; Devon Gessert; Tamie Sather; Gus Jiminez; Danielle Harvey; Matthew Bernstein; Nick Fox; Paul Thompson; Norbert Schuff; Charles DeCarli; Bret Borowski; Jeff Gunter; Matt Senjem; Prashanthi Vemuri; David Jones; Kejal Kantarci; Chad Ward; Robert A. Koeppe; Norm Foster; Eric M. Reiman; Kewei Chen; Chet Mathis; Susan Landau; Nigel J. Cairns; Erin Householder; Lisa Taylor-Reinwald; Virginia M.Y. Lee; Magdalena Korecka; Michal Figurski; Karen Crawford; Scott Neu; Tatiana M. Foroud; Steven Potkin; Li Shen; Kelley Faber; Sungeun Kim; Kwangsik Nho; Leon Thal; Richard Frank; Neil Buckholtz; Marilyn Albert; John Hsiao; Lars T. Westlye; William S. Kremen; Terry L. Jernigan; Stephanie Le Hellard; Vidar M. Steen; Thomas Espeseth; Matt Huentelman; Asta K. Håberg; Ingrid Agartz; Srdjan Djurovic; Ole A. Andreassen; Nicholas Schork; Anders M. Dale
• Keywords: Genetic architecture

Abstract Little is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects that influence brain morphology. Here, we examine imaging single-nucleotide polymorphisms (SNPs) data from ∼2,700 individuals. We show a substantial proportion of in cortical surface area explained by additive SNPs dispersed throughout the genome, with larger heritable effect visual auditory sensory insular cortices ( h 2 ∼0.45). Genome-wide collectively account for, on average, half twin heritability across N =466 twins). find near genes. also observe more contributed significantly area, particularly, medial temporal regions. less occipital dorsolateral prefrontal cortices.