Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4

• DOI: 10.1038/ng.2424
• Publication Date: 2012-09-30T19:46:08Z
• Authors: Jianfeng Xu; Zengnan Mo; Dingwei Ye; Meilin Wang; Fang Liu; Guangfu Jin; Chuanliang Xu; Xiang Wang; Qiang Shao; Zhiwen Chen; Zhihua Tao; Jun Qi; Fangjian Zhou; Zhong Wang; Yaowen Fu; Dalin He; Qiang Wei; Jianming Guo; Denglong Wu; Xin Gao; Jianlin Yuan; Gongxian Wang; Yong Xu; Guozeng Wang; Haijun Yao; Pei Dong; Yang Jiao; Mo Shen; Jin Yang; Jun Ou-Yang; Haowen Jiang; Yao Zhu; Shancheng Ren; Zhengdong Zhang; Changjun Yin; Xu Gao; Bo Dai; Zhibin Hu; Yajun Yang; Qijun Wu; Hongyan Chen; Peng Peng; Ying Zheng; Xiaodong Zheng; Yongbing Xiang; Jirong Long; Jian Gong; Rong Na; Xiaoling Lin; Hongjie Yu; Zhong Wang; Sha Tao; Junjie Feng; Jishan Sun; Wennuan Liu; Ann Hsing; Jianyu Rao; Qiang Ding; Fredirik Wiklund; Henrik Gronberg; Xiao-Ou Shu; Wei Zheng; Hongbing Shen; Li Jin; Rong Shi; Daru Lu; Xuejun Zhang; Jielin Sun; S Lilly Zheng; Yinghao Sun
• Keywords: Male; 0301 basic medicine; Kruppel-Like Transcription Factors; Prostatic Neoplasms; Polymorphism, Single Nucleotide; 3. Good health; DNA-Binding Proteins; Kruppel-Like Factor 4; 03 medical and health sciences; DNA Repair Enzymes; Asian People; Risk Factors; Humans; Genetic Predisposition to Disease; Receptors, Immunologic; Chromosomes, Human, Pair 9; Chromosomes, Human, Pair 19; Gene Deletion; Genome-Wide Association Study

Prostate cancer risk-associated variants have been reported in populations of European descent, African-Americans and Japanese using genome-wide association studies (GWAS). To systematically investigate prostate cancer risk-associated variants in Chinese men, we performed the first GWAS in Han Chinese. In addition to confirming several associations reported in other ancestry groups, this study identified two new risk-associated loci for prostate cancer on chromosomes 9q31.2 (rs817826, P = 5.45 × 10(-14)) and 19q13.4 (rs103294, P = 5.34 × 10(-16)) in 4,484 prostate cancer cases and 8,934 controls. The rs103294 marker at 19q13.4 is in strong linkage equilibrium with a 6.7-kb germline deletion that removes the first six of seven exons in LILRA3, a gene regulating inflammatory response, and was significantly associated with the mRNA expression of LILRA3 in T cells (P < 1 × 10(-4)). These findings may advance the understanding of genetic susceptibility to prostate cancer.