Diet‐Induced Changes in Stearoyl‐CoA Desaturase 1 Expression in Obesity‐Prone and ‐Resistant Mice

• DOI: 10.1038/oby.2004.160
• Publication Date: 2008-04-21T09:21:54Z
• Authors: Charlie C. Hu; Keyun Qing; Yanyun Chen
• Keywords: Calorie

To investigate stearoyl-coenzyme A desaturase (SCD) 1 expression in obesity-prone C57BL/6 mice and obesity-resistant FVB to explore the relationship of SCD1 susceptibility diet-induced obesity.Nine-week-old were fed either a high- or low-fat diet for 8 weeks. Body weight body composition measured before at weeks 4 study. Energy expenditure was 5 Hepatic mRNA 72 hours end Plasma leptin insulin concentrations study.When switched calorie-dense high-fat diet, animals gained significantly more than those maintained on low-calorie density primarily due increased fat mass accretion. Fat continued accrue throughout Increased calorie intake did not account all gain. On decreased their energy when compared with diet. In response gene liver >2-fold. contrast, feeding change weight, expenditure, mice.Our study showed that hypercaloric adiposity first by producing hyperphagia then decreasing susceptible obesity. Consumption species predisposed obesity selectively liver.