Insulin and Hippocampus Activation in Response to Images of High‐Calorie Food in Normal Weight and Obese Adolescents

• DOI: 10.1038/oby.2010.26
• Publication Date: 2010-02-18T15:37:44Z
• Authors: Sandra Wallner‐Li...; Karl Koschutnig; Gernot Reishofer; Erich Sorantin; Barbara Blaschitz; Renate Kruschitz; Human F. Unterrainer; Robert Gasser; Florian Freytag; Carmen Bauer‐Denk; Harald Mangge
• Keywords: Caloric theory

Responsiveness to food cues, especially those associated with high-calorie nutrients may be a factor underlying obesity. An increased motivational potency of foods appears mediated in part by the hippocampus. To clarify this, we investigated means 3-T magnetic resonance imaging (MRI) activation hippocampus and brain structures response pictures low-calorie 12 obese normal-weight adolescents. investigate relationship between neuronal patterns (e.g., hippocampus) caloric content images plasma insulin levels, performed multiple regression analysis. Interestingly, significant positive correlation fasting levels insulin, waist circumference, right hippocampal was seen after stimulation high-caloric images. BMI values did not correlate significantly activation. On other hand, found negative medial gyrus frontalis superior left thalamus. In summary, our data show that is importantly involved central regulation intake. The images, circumference suggests permissive role signaling pathways control eating behavior. only as main indicator abdominal obesity, correlated patterns, BMI.