Instant preparation of a biodegradable injectable polymer formulation exhibiting a temperature-responsive sol–gel transition

• DOI: 10.1038/pj.2014.30
• Publication Date: 2014-05-21T14:13:04Z
• Authors: Yasuyuki Yoshida; Akihiro Takahashi; Akinori Kuzuya; Yuichi Ohya
• Keywords: 01 natural sciences; 0104 chemical sciences

We developed a very quick and convenient preparative method for an injectable polymer (IP) formulation to overcome solubility problems of IPs. We investigated the effects of various additives on the dispersion time and gelation behavior for triblock polymers composed of poly(ɛ-caprolactone-co-glycolic acid) (PCGA) and PEG, and found that the addition of PEG with appropriate molecular weight was the best for quick preparation of IP suspension exhibiting temperature-responsive sol–gel transition. This method should be very convenient for usage at clinical scene.