Lactate potentiates angiogenesis and neurogenesis in experimental intracerebral hemorrhage

• DOI: 10.1038/s12276-018-0113-2
• Publication Date: 2018-07-06T07:02:39Z
• Authors: Jing Zhou; Tao Liu; Hao Guo; Hanjin Cui; Pengfei Li; Dandan Feng; En Hu; Qing Huang; Ali Yang; Jun Zhou; Jiekun Luo; Tao Tang; Yang Wang
• Keywords: Lactate dehydrogenase A

Lactate accumulation has been observed in the brain with intracerebral hemorrhage (ICH). However, outcome of lactate not well characterized. Here, we report that contributes to angiogenesis and neurogenesis ICH. In first set experiment, a rat model ICH was induced by injecting collagenase into brain. The effects on neurological function, apoptosis, numbers newborn endothelial cells neurons, as proliferation-associated signaling pathway, were evaluated second set, exogenous l-lactate infused intact brains so its could be further assessed. Following ICH, accumulated around hematoma; PCNA+/vWF+ nuclei PCNA+/DCX+ significantly increased compared Sham group. Moreover, translocation nuclear factor-kappa B (NF-κB) p65 nucleus, resulting notable upregulation VEGF bFGF mRNAs proteins levels controls. Administration dehydrogenase inhibitor dramatically inhibited these effects, decreased vascular density, aggravated severity scores apoptosis after After infusion, strikingly addition, facilitated NF-κB induce transcription bFGF. Co-infusion an effects. These data suggest potentiates activating pathway following blood vessel bursts brain, lactate, metabolic intermediary, accumulates bleeding site increase new vessels neurons. A team led Tao Tang Yang Wang at Central South University Changsha, China, experimentally rats examined They showed this molecule protected against cell death expression growth factors involved formation neural regeneration. Inhibiting blocked while infusing enhanced them. findings promotes experimental hemorrhage.