Adiposity associates with lower plasma resolvin E1 (Rve1): a population study

• DOI: 10.1038/s41366-024-01482-x
• Publication Date: 2024-02-12T05:02:15Z
• Authors: Anne Barden; Sujata Shinde; Lawrence J. Beilin; Michael Phillips; Leon Adams; Steffen Bollmann; Trevor A. Mori
• Keywords: Male; Adult; Inflammation; 0303 health sciences; Australia; Article; 03 medical and health sciences; Eicosapentaenoic Acid; Cardiovascular Diseases; Risk Factors; Humans; Female; Obesity; Adiposity

Abstract Background Inadequate inflammation resolution may contribute to persistent low-grade that accompanies many chronic conditions. Resolution of is an active process driven by Specialized Pro-resolving Mediators (SPM) derive from long chain n-3 and n-6 fatty acids. This study examined plasma SPM in relation sex differences, lifestyle a broad range cardiovascular disease (CVD) risk factors 978, 27-year olds the Australian Raine Study. Methods Plasma pathway intermediates (18-HEPE, 17-HDHA 14-HDHA), (E- D-series resolvins, PD1, MaR1) LTB 4 were measured liquid chromatography-tandem mass spectrometry (LCMSMS). Pearson correlations multiple regression analyses assessed relationships between CVD factors. Unpaired t-tests or ANOVA effect sex, smoking, unhealthy alcohol consumption obesity on SPM. Results Women had higher ( p = 0.01) lower RvE1 < 0.0001) RvD1 0.05) levels compared with men. In univariate analysis, associated 0.002), whereas smoking 0.001) increased RvE1. was negatively measures adiposity including BMI, waist circumference, waist-to-height ratio, abdominal subcutaneous fat volume, skinfold thicknesses both men women. Conclusion population suggests deficiency occur response increasing adiposity. observation could be relevant ongoing associates other diseases.