Perspectives on obesity imaging: [18F]2FNQ1P a specific 5-HT6 brain PET radiotracer

• DOI: 10.1038/s41366-024-01644-x
• Publication Date: 2024-10-07T07:01:54Z
• Authors: Pierre Courault; Sandrine Bouvard; Caroline Bouillot; Radu Bolbos; Waël Zeinyeh; Thibaut Iecker; François Liger; Thierry Billard; Luc Zimmer; Fabien Chauveau; Sophie Lancelot
• Keywords: Pathophysiology

Abstract Background Estimates suggest that approximatively 25% of the world population will be overweight in 2025. Better understanding pathophysiology obesity help to develop future therapeutics. Serotonin subtype 6 receptors (5-HT ) have been shown critically involved appetite reduction and weight loss. However, it is not known if pathological cascade triggered by modifies density 5-HT brain. Methods Influence diet-induced (DIO) Wistar rats was explored using MRI (whole-body fat) PET ([ 18 F]2FNQ1P as a specific radiotracer). The primary goal monitor receptor before after 10-week diet (DIO group). secondary compare densities between DIO group, control Zucker (with genetic obesity) lean strain rats. Results fed with high-fat showed higher body fat gain than on MRI. [ analysis highlighted significant clusters voxels (located hippocampus, striatum, cingulate, temporal cortex brainstem) increased binding ( p < 0.05, FWE corrected). Conclusion This study sheds new light influence receptors. also positions an innovative tool explore neuronal consequences or eating disorder pathophysiology.