Using low-cost sensor technologies and advanced computational methods to improve dose estimations in health panel studies: results of the AIRLESS project

• DOI: 10.1038/s41370-020-0259-6
• Publication Date: 2020-08-12T18:03:38Z
• Authors: Lia Chatzidiakou; Anika Krause; Yiqun Han; Wu Chen; Li Yan; Olalekan A. M. Po...; Mike Kellaway; Yangfeng Wu; Jing Liu; Min Hu; ; Ben Barratt; Yutong Cai; Queenie Chan; Lia Chatzidiakou; Shiyi Chen; Wu Chen; Xi Chen; Paul Elliott; Majid Ezzati; Yunfei Fan; Xueyu Han; Min Hu; Aoming Jin; Roderic L. Jones; Frank J. Kelly; Anika Krause; Yingruo Li; Pengfei Liang; Jing Liu; Yan Luo; Xinghua Qiu; Qi Wang; Teng Wang; Yanwen Wang; Yangfeng Wu; Gaoqiang Xie; Wuxiang Xie; Tao Xue; Li Yan; Hanbin Zhang; Junfeng Zhang; Meiping Zhao; Tong Zhu; Yidan Zhu; Ben Barratt; Frank J. Kelly; Tong Zhu; Roderic L. Jones
• Keywords: Dose estimation; Epidemiology; 05 Environmental Sciences; TIME-SERIES; Environmental Sciences & Ecology; Toxicology; 01 natural sciences; 333; Environmental & Occupational Health; AIRLESS team; Time-activity-location patterns; Air Pollution; 11. Sustainability; Humans; 11 Medical and Health Sciences; Public, Environmental & Occupational Health; 0105 earth and related environmental sciences; Air Pollutants; Science & Technology; AIR-POLLUTION EXPOSURE; Exposure misclassification; PERSONAL EXPOSURE; Novel sensor technologies; Gaseous pollutants; Public; Health outcomes; 3. Good health; 13. Climate action; Beijing; Particulate Matter; 03 Chemical Sciences; Particulate matter; Life Sciences & Biomedicine; Environmental Sciences; Environmental Monitoring

BACKGROUND: Air pollution epidemiology has primarily relied on fixed outdoor air quality monitoring networks and static populations. METHODS: Taking advantage of recent advancements in sensor technologies and computational techniques, this paper presents a novel methodological approach that improves dose estimations of multiple air pollutants in large-scale health studies. We show the results of an intensive field campaign that measured personal exposures to gaseous pollutants and particulate matter of a health panel of 251 participants residing in urban and peri-urban Beijing with 60 personal air quality monitors (PAMs). Outdoor air pollution measurements were collected in monitoring stations close to the participants' residential addresses. Based on parameters collected with the PAMs, we developed an advanced computational model that automatically classified time-activity-location patterns of each individual during daily life at high spatial and temporal resolution. RESULTS: Applying this methodological approach in two established cohorts, we found substantial differences between doses estimated from outdoor and personal air quality measurements. The PAM measurements also significantly reduced the correlation between pollutant species often observed in static outdoor measurements, reducing confounding effects. CONCLUSIONS: Future work will utilise these improved dose estimations to investigate the underlying mechanisms of air pollution on cardio-pulmonary health outcomes using detailed medical biomarkers in a way that has not been possible before.