Implementation of the 2018 ESC/ESH Guidelines for the management of hypertension in primary care: the HYPEDIA study

• DOI: 10.1038/s41371-022-00713-w
• Publication Date: 2022-07-14T18:02:31Z
• Authors: Anastasios Kollias; Emmanouil Foukarakis; Konstantinos Kara...; ; Eleftherios Adamo...; Georgios Afaras; Giorgos Aggelopoulos; Theodoros Alexand...; Stavros Alexiadis; Apostolos Alexoudis; Evangelia Anastasiou; Antonios Antoniadis; Ilias Antoniou; Georgios Apazidis; Dimitrios Apostol...; Georgios Arvanitakis; Panagiotis Arvanitis; Ieronymos Chager; Emmanouil Chalkia...; Symeon Charalampous; Christos Charmpas; Thekla Chatziadam...; Dimitrios Chountis; Ioannis Choursalas; Dimitrios Chrysis; Nikolaos Chrysoma...; Vasiliki Dalakidou; Ioannis Dermitzakis; Ioannis Diakomich...; Konstantinos Dimi...; Nikolaos Dimoulis; Paulos Dolapsakis; Theodoros Douvitsas; Papalymperi Elisavet; Athanasios Efstat...; Petros Exarchos; Paulos Feggos; Theodoros Feloukas; Dimitrios Floros; Eleni Fourla; Charalampos Fragk...; Marianna Gavriilidou; Dimitrios Georgak...; Euaggelos Georgiadis; Ilias Georgiadis; Kosmas Georgopoulos; Chrysoula Georgop...; Emmanouil Giannad...; Ioannis Giannadakis; Ιgnatios Giavazis; Alexandros Gkalapis; Thomas Gkinis; Dimitrios Eliopoulos; Imprahim Imamoglou; Vaia Ioannidou; Olympia Kapagiann...; Charalampos Kaper...; Konstantinos Kape...; Theodoros Karacha...; Soultana Karakatsani; Eustratios Karani...; Dimitrios Karlis; Theodoros Karonis; Andreas Karydakis; Emmanouil Kasotakis; Triantafyllos Kat...; Nikolaos Kipouridis; Petros Keryttopoulos; Vasileios Kleiousis; Ioannis Kokkalas; Spyros Kokkinos; Ilias Konstantinidis; Stauros Konstanti...; Georgios Kontoroupis; Eleni Kosmaoglou; Leonidas Kostalas; Tsampikos Kourtis; Konstantinos Kout...; Charikleia Krontira; Kimonas Kypriotakis; Anastasios Kyvent...; Spyridon Lappos; Ioannis Leontaridis; Christos Liavas; Stauros Malliaros; Ioanna Markaki; Georgia Markopoul...; Ioannis Mavrepis; Vasilis Mauridis; Fotis Maziotis; Elias Mazokopakis; Alkiviadis Melido...; Nikolaos Maramvel...; Anastasia Mitakidou; Dimitrios Mitropo...; Antonia Moschou; Kyriaki Mousoutzani; Antonis Mperoukas; Kosmas Botsas; Euaggelos Mpougia...; Nikos Mpourneles; Georgios Migias; Savvas Nikiforos; Vasileios Nikolaidis; Christos Nikopoulos; Kadiani Nioti; Nikolaos Oikonomidis; Euaggelos Palmos; Christos Panagos; Maria Pantelidi; Georgios Papadimi...; Achilleas Papadop...; Panagiotis Papado...; Nikolaos Papaioannou; Soultana Papanast...; Marianthi Papapavlou; Panagiotis Papas; Vasileios Paulidis; Georgios Pechliva...; Ilias Pelekanos; Leonidas Peltekis; Anna Pergaminou; Vasilis Plastiras; Athanasios Platis; Nikolaos Poulopoulos; Petros Prokopis; Ali Risggits; Euaggelos Rosmarakis; Konstantinos Roum...; Ioannis Roussis; Alexis Samentzas; Katerina Santipan...; Periklis Sarafianos; Isidoros Sarris; Dimitrios Savvalas; Georgios Sdralias; Ioannis Sfiniadakis; Simos Siachos; Loukas Sinos; Ourania Sitta; Andreas Skanavis; Ioannis Skias; Panagiotis Skiath...; Dimitrios Skoutas; Dimitrios Srateh; Ioannis Stathis; Christos Stathopo...; Christos Stauroth...; Emmanouil Stefanakis; Prokopis Stroumpo...; Konstantinos Svolis; Petros Tapinis; Efstathios Taxiar...; Maria Thoma; Konstantinos Thom...; Michail Timosidis; Paraschos Toloudis; Nikolaos Touroukis; Ioannis Triantafy...; Simon Tsalkitzis; Nikolaos Tsamouras; Konstantinos Tsav...; Ilias Tserkis; Ioannis Tsiantis; Emmanouil Tsirekas; Ploutarchos Tzavaras; Eutychios Tzemanakis; Aristeidis Tziovas; Aikaterini Vagena; Ioannis Vakalis; Konstantinos Vard...; Panagiotis Vavoulis; Stefanos Vlachos; Euaggelos Voliotis; Europia Voukelatou; Konstantinos Vrog...; Michail Xafenias; Dionysios Xenos; Ioannis Zacharakis; Natasa Zacharia; Christos Zafeiris; Ioannis Zafeiris; Charilaos Zakopoulos; Vaia Zoi; Ioannis Zolof; George S. Stergiou
• Keywords: Thiazide; Calcium channel blocker; Antihypertensive drug; Angiotensin Receptor Blockers; Pill; Combination therapy

The HYPEDIA study aimed at evaluating the implementation of 2018 European guidelines for treating hypertension in primary care. A nationwide prospective non-interventional cross-sectional was performed consecutive untreated or treated hypertensives recruited mainly care Greece. Participants' characteristics, office blood pressure (BP) (triplicate automated measurements, Microlife BPA3 PC) and treatment changes were recorded on a cloud platform. total 3,122 patients (mean age 64 ± 12.5 [SD] years, 52% males) assessed by 181 doctors 3 hospital centers. In 772 (25%), drug initiated majority, with monotherapy 53.4%, two-drug combination 36.3%, three drugs 10.3%. Angiotensin receptor blocker (ARB) 30%, ARB/calcium channel (CCB) 20%, ARB/thiazide 8%, angiotensin converting enzyme inhibitor (ACEi)-based 19%. Of combinations used, 97% single-pill. Among 977 aged <65 79% had BP ≥ 130/80 mmHg (systolic and/or diastolic), whereas among 1,373 ≥65 66% 140/80 mmHg. ARBs used 69% hypertensives, CCBs 47%, ACEis 19%, diuretics 39%, beta-blockers Treatment modification decided 53% years 62% those Renin-angiotensin system blocker-based therapy constitutes basis antihypertensive most care, wide use single-pill combinations. almost half uncontrolled not intensified, suggesting suboptimal possible physician inertia.