Neonatal Staphylococcus Aureus Sepsis: a 20-year Western Australian experience

• DOI: 10.1038/s41372-022-01440-3
• Publication Date: 2022-06-25T14:05:05Z
• Authors: Rachel Shadbolt; Michael Lee Shee We; Rolland Kohan; Michelle Porter; Gayatri Athalye-Jape; Elizabeth Nathan; Damber Shrestha; Tobias Strunk
• Keywords: Neonatal Sepsis; Neonatology; Medical record

Abstract Objectives The purpose of this study was to characterise neonatal Staphylococcus aureus (SA) sepsis in Western Australia (WA) between 2001 and 2020 at the sole tertiary intensive care unit (NICU), examine risk factors for cohort, compare short- long-term outcomes control infants without any sepsis. Methods Retrospective cohort Neonatal Directorate King Edward Memorial Hospital (KEMH) Perth Children’s Hospital, using electronic databases patient medical records. Results overall incidence SA 0.10 per 1000 live births (62/614207). From 2010 0.13/1000 births, reducing 0.07/1000 from 2011 2020. most frequently isolated endotracheal aspirates, with had longer median duration ventilatory support than those (31 days vs 18 respectively, p < 0.001). In our associated worse neurodevelopmental compared Conclusions has reduced over last 20 years, suggesting potential effectiveness preventative interventions implemented. Endotracheal tube (ETT) colonisation prolonged ventilation may be under-recognised as sources infection. Our suggests negatively impact outcomes.