Characterization of CD28null T cells in idiopathic pulmonary fibrosis

• DOI: 10.1038/s41385-018-0082-8
• Publication Date: 2018-10-12T07:02:29Z
• Authors: David M. Habiel; Milena S. Espindola; Chris Kitson; Anthony V. Azzara; Ana Lucia Coelho; Barry Stripp; Cory M. Hogaboam
• Keywords: 0301 basic medicine; Programmed Cell Death 1 Receptor; Antibodies, Monoclonal; Cell Separation; Mice, SCID; CD8-Positive T-Lymphocytes; Flow Cytometry; Article; Idiopathic Pulmonary Fibrosis; Immunophenotyping; 3. Good health; Mice; 03 medical and health sciences; CD28 Antigens; T-Lymphocyte Subsets; Airway Remodeling; Animals; Humans; CTLA-4 Antigen; Lung; Cells, Cultured

Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease, with unknown etiopathogenesis and suboptimal therapeutic options. Previous reports have shown that increased T-cell numbers CD28