Central IGF1 improves glucose tolerance and insulin sensitivity in mice

• DOI: 10.1038/s41387-017-0002-0
• Publication Date: 2017-12-13T16:09:53Z
• Authors: Hao Hong; Zhen-Zhong Cui; Lu Zhu; Shu-Ping Fu; Mario Rossi; Ying-Hong Cui; Bing-Mei Zhu
• Keywords: Carbohydrate Metabolism

Abstract Insulin-like growth factor 1 (IGF1) is a key for tissue and fuel metabolism. The potential function of central IGF1 remains unclear. We previously observed that expression increased in the hypothalamus obese mice lacking STAT5 nervous system (CNS). In this study, we explored metabolic by intracerebroventricular (ICV) injection IGF1, over-expression administering an adeno-associated virus (AAV), ICV anti-IGF1 antibody. Mice over-expressed displayed appetite, improved glucose tolerance insulin sensitivity, decreased Pomc levels hypothalamus, UCP1 brown fat tissue. This first study demonstrating regulates several important functions.