A mandatory role of nuclear PAK4-LIFR axis in breast-to-bone metastasis of ERα-positive breast cancer cells

• DOI: 10.1038/s41388-018-0456-0
• Publication Date: 2018-09-03T10:01:46Z
• Authors: Yanshu Li; Hongyan Zhang; Yue Zhao; Chunyu Wang; Zhenguo Cheng; Lina Tang; Yunling Gao; Furong Liu; Jiabin Li; Yan Li; Yang Li; Nanxi Geng; Xue Rui; Yuee Teng; Yunpeng Liu; Liu Cao; Rakesh Kumar; Feng Jin; Feng Li
• Keywords: Estrogen receptor alpha

The mechanism of estrogen receptor alpha (ERα)-positive breast cancer-associated bone metastasis is poorly understood. In this article, we report that nuclear p21-activated kinase 4 (nPAK4) a novel repressor ERα-mediated transactivation in 17β-estradiol (E2)-dependent manner and promotes PAK4–ERα axis-mediated by targeting leukemia inhibitory factor (LIFR) ERα-positive cancer. An evaluation clinical cancer samples revealed nPAK4 linked to ERα expression appears be associated with poor prognosis metastatic PAK4 bound co-translocated from the cytoplasm nucleus upon stimulation E2. enhanced invasive potential cells vitro promoted vivo. Mechanistically, LIFR, suppressor. Strikingly, accumulation might promote aggressive phenotypes, highlighting as predictive biomarker for metastasis.