CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus

• DOI: 10.1038/s41392-020-0174-2
• Publication Date: 2020-06-02T23:05:32Z
• Authors: Yujun Pei; Kun Wen; Zheng Xiang; Chunyu Huang; Xiwei Wang; Xiaofeng Mu; Liyan Wen; Yinping Liu; Wenwei Tu
• Keywords: CD137

Influenza epidemics and pandemics are constant threats to global public health. Although strategies including vaccines antiviral drugs have achieved great advances in controlling influenza virus infection, the efficacy of these is limited by highly frequent mutations viral genome emergence drug-resistant strains. Our previous study indicated that boosting immunity human Vγ9Vδ2-T cells with phosphoantigen pamidronate could be a therapeutic strategy treat seasonal avian infections. However, one notable drawback γδ-T cell-based immunotherapy rapid exhaustion proliferation effector responses due repeated treatments phosphoantigens. Here, we found expression CD137 was inducible following antigenic stimulation. CD137+ displayed more potent activity against than their CD137- counterparts vitro Rag2-/- γc-/- mice. We further demonstrated costimulation essential for cell activation, proliferation, survival functions. In humanized mice reconstituted peripheral blood mononuclear cells, recombinant CD137L protein boosted effects virus. provides novel targeting improve immunotherapy.