Perineuronal nets are under the control of type-5 metabotropic glutamate receptors in the developing somatosensory cortex

• DOI: 10.1038/s41398-021-01210-3
• Publication Date: 2021-02-18T07:59:26Z
• Authors: Giada Mascio; Domenico Bucci; Serena Notartomaso; Francesca Liberatore; Nico Antenucci; Pamela Scarselli; Tiziana Imbriglio; Stefano Caruso; Roberto Gradini; Milena Cannella; Luisa Di Menna; Valeria Bruno; Giuseppe Battaglia; Ferdinando Nicoletti
• Keywords: Perineuronal net

Abstract mGlu5 metabotropic glutamate receptors are highly functional in the early postnatal life, and regulate developmental plasticity of parvalbumin-positive (PV + ) interneurons cerebral cortex. PV cells enwrapped by perineuronal nets (PNNs) at closure critical windows cortical plasticity. Changes PNNs have been associated with neurodevelopmental disorders. We found that number Wisteria Fluoribunda Agglutinin (WFA) density WFA /PV were largely increased somatosensory cortex −/− mice PND16. An PNN was also observed after pharmacological blockade first two weeks. The close to a plateau PND16, whereas continued increase wild-type mice, there no difference between genotypes PND21 PND60. PND16 showed increases transcripts genes involved formation reduced expression activity type-9 matrix metalloproteinase suggesting control both degradation. Finally, unilateral whisker stimulation from PND9 enhanced contralateral only +/+ trimming exclusively shape response sensory experience. These findings disclose novel undescribed mechanism regulation, lay groundwork for study