The additive effect of late-life depression and olfactory dysfunction on the risk of dementia was mediated by hypersynchronization of the hippocampus/fusiform gyrus

• DOI: 10.1038/s41398-021-01291-0
• Publication Date: 2021-03-17T10:04:05Z
• Authors: Ben Chen; Xiaomei Zhong; Min Zhang; Naikeng Mai; Zhangying Wu; Xinru Chen; Qi Peng; Huarong Zhou; Qiang Wang; Mingfeng Yang; Si Zhang; Lavinia Alberi Auber; Ilona Croy; Thomas Hummel; Yuping Ning
• Keywords: Fusiform gyrus; Lingual gyrus; Temporal cortex; Orbitofrontal cortex

Abstract Early detection of patients with late-life depression (LLD) a high risk developing dementia contributes to early intervention. Odor identification (OI) dysfunction serves as marker for predicting dementia, but whether OI increases the in LLD remains unclear. The present study aimed explore interactive effect and on its underlying neuroimaging changes. One hundred fifty-seven 101 normal controls were recruited, data their OI, cognition, activity daily living (ADL), resting-state functional magnetic resonance imaging collected. Two × two factorial analyses used analyze effects neuropsychological abnormalities. Mediation abnormalities detected by mediated associations between cognition/ADL. results suggested that exhibited additive reduced ADL, global cognition memory scores, well variables including (i) increased fractional amplitude low-frequency fluctuation (fALFF) right orbitofrontal cortex precentral cortex, (ii) regional homogeneity (ReHo) left hippocampus/fusiform gyrus, etc. In addition, these fALFF ReHo values associated scores (ADL, memory, language). Moreover, gyrus completely relationship partially cognition. Overall, hypersynchronization may increase patients.