Impact of COVID-19 in patients with multiple myeloma based on a global data network

• DOI: 10.1038/s41408-021-00588-z
• Publication Date: 2021-12-10T08:05:11Z
• Authors: J. Martinez-Lopez; G. Hernandez-Ibar...; R. Alonso; J. M. Sanchez-Pina; I. Zamanillo; N. Lopez-Muñoz; Rodrigo Iñiguez; C. Cuellar; M. Calbacho; M. L. Paciello; R. Ayala; N. García-Barrio; D. Perez-Rey; L. Meloni; J. Cruz; M. Pedrera-Jiménez; P. Serrano-Balazote; J. de la Cruz
• Keywords: Pandemic; Social distance; Excess mortality; 2019-20 coronavirus outbreak; Medical record; Electronic medical record

Abstract The COVID-19 pandemic has represented a major cause of morbidity/mortality worldwide, overstressing health systems. Multiple myeloma (MM) patients show an increased risk for infections and they are expected to be particularly vulnerable SARS-CoV-2 infection. Here we have obtained comprehensive picture the impact in MM on local global scale using federated data research network (TriNetX) that provided access Electronic Medical Records (EMR) from Health Care Organizations (HCO) all over world. Through propensity score matched analyses found number new diagnoses was reduced 2020 compared 2019 (RR 0.86, 95%CI 0.76–0.96) survival newly diagnosed cases decreased similarly (HR 0.61, 0.38–0.81). showed higher infection 2.09, 1.58–2.76) excess mortality (difference 9%, 4.4–13.2) than non-MM patients. By interrogating large EMR datasets HCO Europe globally, confirmed been more severely impacted by This study highlights necessity extending preventive measures worlwide protect promoting social distancing intensive vaccination strategies.