Comparison of anal cancer screening strategies including standard anoscopy, anal cytology, and HPV genotyping in HIV-positive men who have sex with men

• DOI: 10.1038/s41416-018-0176-9
• Publication Date: 2018-07-18T18:50:31Z
• Authors: Simon Pernot; Pauline Boucheron; Hélène Péré; Marie-Laure Lucas; David Veyer; Nadia Fathallah; Vincent de Parades; Juliette Pavie; Jeanne Netter; Lio Collias; Julien Taieb; Sophie Grabar; Laurence Weiss
• Keywords: Adult; Male; Human papillomavirus 16; Genotype; Cytodiagnosis; Papillomavirus Infections; Anal Canal; HIV; HIV Infections; Middle Aged; Anus Neoplasms; Article; 3. Good health; Sexual and Gender Minorities; 03 medical and health sciences; 0302 clinical medicine; Humans; France; Homosexuality, Male; Early Detection of Cancer; Papanicolaou Test

There is no consensus on screening strategy of high-grade intraepithelial neoplasia (HGAIN). Guidelines range from clinical examination with digital anorectal followed by standard anoscopy (SA), to anal cytology (Pap)+/- HPV genotyping. We compared yields based Pap, SA, and HPV-16 genotyping alone or in combination HIV-MSM.Pap, were performed all HIV-MSM attending a first cancer consultation Paris, France. High-resolution anoscopy, the gold detect HGAIN, was case positivity abnormal cytology. Yield defined as number patients HGAIN relative total screened.On 212 patients, complete (SA + Pap genotyping) yield (12.7%) significantly higher than that SA (3.3%, p < 0.001) (6.6%, 0.05). Although none other strategies different strategy, had closer (about 11%), OR = 0.83 (95% CI [0.44;1.57]) 0.87 [0.46;1.64]), respectively.Pap combined tended towards alone, strategy.