Impact of adjuvant chemotherapy and radiotherapy on tumour-infiltrating lymphocytes and PD-L1 expression in metastatic breast cancer

• DOI: 10.1038/s41416-022-02072-2
• Publication Date: 2022-12-15T13:44:16Z
• Authors: Shu Yazaki; Roberto Salgado; Tatsunori Shimoi; Masayuki Yoshida; Sho Shiino; Tomoya Kaneda; Yuki Kojima; Hitomi Sumiyoshi-...; Tadaaki Nishikawa; Kazuki Sudo; Emi Noguchi; Takeshi Murata; Shin Takayama; Akihiko Suto; Yuichiro Ohe; Kan Yonemori
• Keywords: Tumor-infiltrating lymphocytes

Chemotherapy and radiotherapy were postulated to induce an inflamed tumour microenvironment. We aimed evaluate the effects of adjuvant chemotherapy/radiotherapy on tumour-infiltrating lymphocytes (TILs) programmed death-ligand 1 (PD-L1) expression in metastatic breast cancer.We identified paired primary tumours 85 patients with cancer. Stromal TILs assessed according international guidelines. PD-L1 was evaluated using VENTANA SP142 assay.TILs significantly lower than (12.2 vs. 8.3%, p = 0.049). positivity similar between (21.2 14.1%, 0.23). who received chemotherapy those did not (-9.07 1.19%, 0.01). However, had no significant effect (p 0.44). Decreased predicted worse post-recurrence survival (hazard ratio, 2.94; 95% confidence interval [CI]: 1.41-6.13, 0.003), while increased associated a better prognosis (HR, 0.12; CI: 0.02-0.08, 0.04).TILs decreased tumours, particularly relapsed after chemotherapy. Changes from sites could be prognostic factor recurrence.