Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p

• DOI: 10.1038/s41419-018-1287-1
• Publication Date: 2019-01-22T12:03:48Z
• Authors: Zihao Liu; You Zhou; Gehao Liang; Yun Ling; Weige Tan; Luyuan Tan; Robert Andrews; Wenjing Zhong; Xuanxuan Zhang; Erwei Song; Chang Gong
• Keywords: Circular RNA; Tumor progression

Abstract Increasing evidence suggests circular RNAs (circRNAs) exert critical functions in tumor progression via sponging miRNAs (microRNAs). However, the role of circRNAs breast cancer remains unclear. Here we systematically analyzed based on their characteristic disease-specific and identified hsa_circ_001783 as a top ranked circRNA our computation verified its high expression both cells tissue. A higher level was significantly correlated with heavier burden poorer prognosis patients cancer. Knockdown this remarkably inhibited proliferation invasion cells. Importantly, promoted miR-200c-3p. Taken together, may serve novel prognostic therapeutic target for