Ionizing radiation-induced long noncoding RNA CRYBG3 regulates YAP/TAZ through mechanotransduction

• DOI: 10.1038/s41419-022-04650-x
• Publication Date: 2022-03-04T13:37:47Z
• Authors: Lijun Zheng; Chenyu Luo; Nan Yang; Hailong Pei; Mintao Ji; Yinyin Shu; Zhisen Zhang; Shuai Dong; Xiuxiu Wang; Xuemei Li; Wensheng Zhang; Yan Wang; Bingyan Li; Tom K. Hei; Guangming Zhou; Lei Chang
• Keywords: Mechanotransduction

Abstract Mechanotransduction sensing of tissue architecture and cellular microenvironment is a fundamental regulator cell fate, including cancer. Meanwhile, long noncoding RNAs (lncRNAs) play multifunctions during cancer development treatment. However, the link between lncRNAs mechanotransduction in context progression has not yet been elucidated. In this study, using atomic force microscopy (AFM), we find that ionizing radiation reduces tumor stiffness. Ionizing radiation-induced lncRNA CRYBG3 can blunt YAP/TAZ activity through interference with mechanotransduction, resulting inhibition proliferation, invasion, metastasis lung cells. vivo, found loss could power initiation ability, but was abolished by concomitant deplete TAZ. At molecular level, turn dysregulates F-actin organization, activates LATS1/2 kinase, all nuclear exclusion. Our research proposes mediator radiotherapy its control cancer-tissue wiring to growth metastasis.