JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling

• DOI: 10.1038/s41420-021-00426-y
• Publication Date: 2021-04-19T08:07:37Z
• Authors: Yanlin Ren; Dongyin Chen; Zurong Zhai; Junjie Chen; Aiping Li; Yan Liang; Jianwei Zhou
• Keywords: NEDD4

Abstract The overexpression of HER2 is associated with a malignant proliferation breast cancer. In this study, we developed non-cytotoxic JWA gene activating compound 1 (JAC1) to inhibit the HER2-positive cancer cells in vitro and vivo experimental models. JAC1 increased ubiquitination at K716 site through E3 ubiquitin ligase SMURF1 which was due decreased expression NEDD4, SMURF1. conclusion, suppresses triggered signaling. may serve as potential therapeutic agent for