Neutrophil extracellular traps-triggered impaired autophagic flux via METTL3 underlies sepsis-associated acute lung injury

• DOI: 10.1038/s41420-022-01166-3
• Publication Date: 2022-08-27T08:02:44Z
• Authors: Mengdi Qu; Zhaoyuan Chen; Zhiyun Qiu; Ke Nan; Yanghanzhao Wang; Yuxin Shi; Yuwen Shao; Ziwen Zhong; Shuainan Zhu; Kefang Guo; Wankun Chen; Xihua Lu; Zhiping Wang; Hao Zhang; Changhong Miao
• Keywords: Neutrophil Extracellular Traps

Neutrophil extracellular traps (NETs) assist pathogen clearance, while excessive NETs formation is associated with exacerbated inflammatory responses and tissue injury in acute lung (ALI)/acute respiratory distress syndrome (ARDS). Autophagy generally considered to be a protective process, but autophagy dysfunction harmful. Whether how affect autophagic flux during sepsis-induced ALI are currently unknown. Here, we confirmed that the level of was increased ARDS patients mice models, which led impairment deterioration disease. Mechanistically, activated METTL3 mediated m6A methylation Sirt1 mRNA alveolar epithelial cells, resulting abnormal autophagy. These findings provide new insights into contribute development sepsis-associated ALI/ARDS.