Ferroptosis exacerbates hyperlipidemic acute pancreatitis by enhancing lipid peroxidation and modulating the immune microenvironment

• DOI: 10.1038/s41420-024-02007-1
• Publication Date: 2024-05-21T07:02:51Z
• Authors: Xinyi Gu; Zhicheng Huang; Xiuzhiye Ying; Xiaodie Liu; Kaiyi Ruan; Sijia Hua; Xiaofeng Zhang; Hangbin Jin; Qiang Liu; Jianfeng Yang
• Keywords: Hyperlipidemia

Abstract Abnormal activation of ferroptosis worsens the severity acute pancreatitis and intensifies inflammatory response organ damage, but detailed underlying mechanisms are unknown. Compared with other types pancreatitis, hyperlipidemic (HLAP) is more likely to progress necrotizing possibly due peripancreatic lipolysis production unsaturated fatty acids. Moreover, high levels acids undergo lipid peroxidation trigger further exacerbate inflammation worsen HLAP. This paper focuses on malignant development severe disease combined core features explore describe mechanism this phenomenon shows that aberrant intracellular release many mediators during key processes regulate degree in patients Inhibiting effectively reduces intensity response, thus reducing damage preventing risk HLAP exacerbation. Additionally, summarizes targets potential therapeutic agents associated deterioration provide new ideas for future clinical applications.