Short-term prediction of preeclampsia using the sFlt-1/PlGF ratio: a subanalysis of pregnant Japanese women from the PROGNOSIS Asia study

• DOI: 10.1038/s41440-021-00629-x
• Publication Date: 2021-03-17T02:02:35Z
• Authors: Akihide Ohkuchi; Shigeru Saito; Tatsuo Yamamoto; Hisanori Minakami; Hisashi Masuyama; Keiichi Kumasawa; Jun Yoshimatsu; Takeshi Nagamatsu; Angela Dietl; Sonja Grill; Martin Hund
• Keywords: Cut-off

Abstract Two prospective multicenter studies demonstrated that a soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio cutoff of ≤38 can rule out preeclampsia within week with negative predictive value (NPV) 99.3% (PROGNOSIS) and 98.6% (PROGNOSIS Asia). We report subanalysis the Japanese cohort from PROGNOSIS Asia study. Pregnant women suspected between gestational weeks 18 + 0 days 36 6 were enrolled at eight sites. Primary objectives: Assess performance Elecsys ® sFlt-1/PlGF to >38 in 4 weeks. Key secondary Prediction maternal fetal adverse outcomes (MAOs/FAOs) their relationship duration pregnancy. Of 192 enrolled, 180 (93.8%)/175 (91.1%) evaluable for primary/combined endpoint analyses. Overall prevalence was 13.3%. A provided an NPV 100% (95% confidence interval [CI], 97.5–100) ruling week, positive 32.4% CI, 18.0–49.8) The area under curve prediction preeclampsia/maternal/fetal 94.2% 89.3–97.8). After adjusting age final status, Cox regression indicated 2.8-fold greater risk imminent delivery versus ≤38. This suspicion showed high 38 short-term preeclampsia.