Network heterogeneity regulates steering in actin-based motility

• DOI: 10.1038/s41467-017-00455-1
• Publication Date: 2017-09-15T16:24:50Z
• Authors: Rajaa Boujemaa-Pa...; Cristian Suarez; Tobias Klar; Jie Zhu; Christophe Guérin; Alex Mogilner; Manuel Théry; Laurent Blanchoin
• Keywords: Lamellipodium

Abstract The growth of branched actin networks powers cell-edge protrusions and motility. A heterogeneous density actin, which yields to a tunable cellular response, characterizes these dynamic structures. We study how organization controls both the rate steering during lamellipodium growth. use high-resolution surface structuration assay combined with mathematical modeling describe reconstituted lamellipodium. demonstrate that local monomer depletion at site assembly negatively impacts network rate. At same time, architecture tunes protrusion efficiency, regulates One consequence this interdependence between effects is ability impose Therefore, we have established general principle, by cell can modulate direction protrusion, varying its network.