The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases

• DOI: 10.1038/s41467-017-00901-0
• Publication Date: 2017-10-06T08:59:43Z
• Authors: Chen Chen; Xiaolei Song; Weixia Wei; Huanzi Zhong; Juanjuan Dai; Zhou Lan; Fei Li; Xinlei Yu; Qiang Feng; Zirong Wang; Hailiang Xie; Xiaomin Chen; Chunwei Zeng; Bo Wen; Liping Zeng; Hui Du; Huiru Tang; Changlu Xu; Yan Xia; Huihua Xia; Huanming Yang; Jian Wang; Jun Wang; Lise Madsen; Susanne Brix; Karsten Kristiansen; Xun Xu; Junhua Li; Ruifang Wu; Huijue Jia
• Keywords: Reproductive tract; Female Reproductive Tract; Endometritis

Reports on bacteria detected in maternal fluids during pregnancy are typically associated with adverse consequences, and whether the female reproductive tract harbours distinct microbial communities beyond vagina has been a matter of debate. Here we systematically sample microbiota within 110 women age, examine nature colonisation by 16S rRNA gene amplicon sequencing cultivation. We find cervical canal, uterus, fallopian tubes peritoneal fluid, differing from that vagina. The results reflect continuum along tract, indicative non-sterile environment. also identify taxa potential functions correlate menstrual cycle or over-represented subjects adenomyosis infertility due to endometriosis. study provides insight into vagino-uterine microbiome, suggests surveying vaginal might be useful for detection common diseases upper tract.Whether microbiomes Here, authors show subject-specific continuity at six sites