Human mesenchymal stromal cells transplanted into mice stimulate renal tubular cells and enhance mitochondrial function

• DOI: 10.1038/s41467-017-00937-2
• Publication Date: 2017-10-11T15:41:45Z
• Authors: Luca Perico; Marina Morigi; Cinzia Rota; Matteo Breno; Caterina Mele; Marina Noris; Martino Introna; Chiara Capelli; Lorena Longaretti; Daniela Rottoli; Sara Conti; Daniela Corna; Giuseppe Remuzzi; Ariela Benigni
• Keywords: SIRT3; Reprogramming

Mesenchymal stromal cells (MSCs) are renoprotective and drive regeneration following injury, although cellular targets of such an effect still ill-defined. Here, we show that human umbilical cord (UC)-MSCs transplanted into mice stimulate tubular to regain mitochondrial mass function, associated with enhanced microtubule-rich projections appear mediate trafficking create a reparative dialogue among adjacent cells. Treatment UC-MSCs in cisplatin-induced acute kidney injury (AKI) regulates biogenesis proximal tubuli by enhancing PGC1α expression, NAD+ biosynthesis Sirtuin 3 (SIRT3) activity, thus fostering antioxidant defenses ATP production. The functional role SIRT3 recovery is highlighted data SIRT3-deficient AKI, UC-MSC treatment fails induce renoprotection. These document previously unrecognized mechanism through which facilitate renal repair, so as global metabolic reprogramming damaged sustain energy supply.Mesenchymal injury. the authors mesenchymal cells, when cell growth enhance function via SIRT3.