Ingestion of artificial sweeteners leads to caloric frustration memory in Drosophila

• DOI: 10.1038/s41467-017-01989-0
• Publication Date: 2017-11-21T16:43:46Z
• Authors: Pierre-Yves Musso; Aurélie Lampin-Sa...; Paul Tchenio; Thomas Preat
• Keywords: Caloric theory

Non-caloric artificial sweeteners (NAS) are widely used in modern human food, raising the question about their health impact. Here we have asked whether NAS consumption is a neutral experience at neural and behavioral level, or if can be interpreted remembered as negative experience. We imaging approaches to demonstrate that Drosophila melanogaster learn non-caloric property of through post-ingestion process. These results show sweet taste predictive an energy value, its absence leads formation what call Caloric Frustration Memory (CFM) devalues caloric enantiomer. CFM involves activity associative memory brain structure, mushroom bodies (MBs). In vivo calcium MB-input dopaminergic neurons respond sugar showed reduced response after formation. Altogether, these findings for brain.