Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells

• DOI: 10.1038/s41467-018-02865-1
• Publication Date: 2018-01-24T17:29:32Z
• Authors: Naohiro Seo; Yoshitaka Shirakura; Yoshiro Tahara; Fumiyasu Momose; Naozumi Harada; Hiroaki Ikeda; Kazunari Akiyoshi; Hiroshi Shiku
• Keywords: 0301 basic medicine; Mice, Inbred BALB C; Cell Survival; Science; Q; Mesenchymal Stem Cells; Neoplasms, Experimental; CD8-Positive T-Lymphocytes; Article; 3. Good health; Extracellular Vesicles; 03 medical and health sciences; Cell Line, Tumor; Animals; Female; Cells, Cultured

Fibroblastic tumour stroma comprising mesenchymal stem cells (MSCs) and cancer-associated fibroblasts (CAFs) promotes the invasive metastatic properties of cells. Here we show that activated CD8+ T cell-derived extracellular vesicles (EVs) interrupt fibroblastic stroma-mediated progression. Activated from healthy mice transiently release cytotoxic EVs causing marked attenuation invasion metastasis by apoptotic depletion stromal Infiltration EV-producing is observed in neovascular areas with high cell density, MSC associated preferential engulfment this setting. Thus, have capacity to protect progression EV-mediated addition their conventional direct cytotoxicity against