CDK6 inhibits white to beige fat transition by suppressing RUNX1

• DOI: 10.1038/s41467-018-03451-1
• Publication Date: 2018-03-05T18:02:05Z
• Authors: Xiaoli Hou; Yongzhao Zhang; Wei Li; Alexander J. Hu; Chi Luo; Wenhui Zhou; Jamie K. Hu; Stefano G. Daniele; Jinfeng Wang; Jinghao Sheng; Yongsheng Fan; Andrew S. Greenberg; Stephen R. Farmer; Miaofen G. Hu
• Keywords: Cyclin-dependent kinase 6; RUNX1

Whereas white adipose tissue depots contribute to the development of metabolic diseases, brown and beige has beneficial effects. Here we show that CDK6 regulates adipocyte formation. We demonstrate mice lacking protein or its kinase domain (K43M) exhibit significant increases cell formation, enhanced energy expenditure, better glucose tolerance, improved insulin sensitivity, are more resistant high-fat diet-induced obesity. Re-expression in Cdk6 -/- mature precursor cells, ablation RUNX1 K43M reverses these phenotypes. Furthermore, positively expression Ucp-1 Pgc1α by binding proximal promoter regions. Our findings indicate activity negatively conversion fat-storing cells into fat-burning suppressing RUNX1, suggest may be a therapeutic target for treatment obesity related diseases.