Conditional privatization of a public siderophore enables Pseudomonas aeruginosa to resist cheater invasion

• DOI: 10.1038/s41467-018-03791-y
• Publication Date: 2018-04-11T14:12:18Z
• Authors: Zhenyu Jin; Jiahong Li; Lei Ni; Rongrong Zhang; Aiguo Xia; Fan Jin
• Keywords: 0301 basic medicine; Photons; Science; Iron; Q; Colony Count, Microbial; Siderophores; Fluoresceins; Biological Evolution; Article; Anti-Bacterial Agents; 03 medical and health sciences; Stress, Physiological; Antibiosis; Pseudomonas aeruginosa; Tobramycin; Symbiosis; Oligopeptides; Fluorescent Dyes

Abstract Understanding the mechanisms that promote cooperative behaviors of bacteria in their hosts is great significance to clinical therapies. Environmental stress generally believed increase competition and reduce cooperation bacteria. Here, we show bacterial can fact be maintained because environmental stress. We Pseudomonas aeruginosa regulates secretion iron-scavenging siderophores presence different stresses, reserving this public good for private use protection against reactive oxygen species when under term strategy “conditional privatization”. Using a combination experimental evolution theoretical modeling, demonstrate conditional privatization resistant invasion by non-producing cheaters. These findings how regulation goods affects evolutionary stability pathogenic population, which may assist rational development novel