Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer

• DOI: 10.1038/s41467-018-04244-2
• Publication Date: 2018-05-09T11:33:45Z
• Authors: Myoung-Hee Kang; Hyunji Choi; Masanobu Oshima; Jae-Ho Cheong; Seokho Kim; Jung Hoon Lee; Young Soo Park; Hueng-Sik Choi; Mi-Na Kweon; Chan-Gi Pack; Ju-Seog Lee; Gordon B. Mills; Seung-Jae Myung; Yun-Yong Park
• Keywords: Male; 0303 health sciences; Science; Q; Article; 3. Good health; Gene Expression Regulation, Neoplastic; Mice; 03 medical and health sciences; Transcription Factor 4; Receptors, Estrogen; Stomach Neoplasms; Cell Line, Tumor; Animals; Humans; Female; Genes, Tumor Suppressor; Wnt Signaling Pathway

The principle factors underlying gastric cancer (GC) development and outcomes are not well characterized resulting in a paucity of validated therapeutic targets. To identify potential molecular targets, we analyze gene expression data from GC patients the nuclear receptor ESRRG as candidate tumor suppressor. is decreased predictor poor clinical outcome. Importantly, suppresses cell growth tumorigenesis. Gene profiling suggests that antagonizes Wnt signaling via suppression TCF4/LEF1 binding to CCND1 promoter. Indeed, levels found be inversely correlated with signaling-associated genes patients. Strikingly, agonist DY131 represses genes. Our present findings thus demonstrate functions negative regulator pathway target for this cancer.