Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms

• DOI: 10.1038/s41467-018-05728-x
• Publication Date: 2018-08-17T09:34:40Z
• Authors: Ho Lam Chan; Felipe Beckedorff; Yusheng Zhang; Jenaro Garcia-Hui...; Hua Jiang; Antonio Colaprico; Daniel Bilbao; Maria E. Figueroa; John LaCava; Ramin Shiekhattar; Lluis Morey
• Keywords: FOXA1; BRD4

Abstract Polycomb repressive complex 1 (PRC1) plays essential roles in cell fate decisions and development. However, its role cancer is less well understood. Here, we show that RNF2 , encoding RING1B, canonical PRC1 (cPRC1) genes are overexpressed breast cancer. We find cPRC1 complexes functionally associate with ERα pioneer factor FOXA1 ER+ cells, BRD4 triple-negative cells (TNBC). While still exerts function, it also recruited to oncogenic active enhancers. RING1B regulates enhancer activity gene transcription not only by promoting the expression of oncogenes but regulating chromatin accessibility. Functionally, a divergent TNBC metastasis. Finally, concomitant recruitment enhancers occurs across multiple cancers, highlighting an under-explored function transcriptional programs