An intrinsic tumour eviction mechanism in Drosophila mediated by steroid hormone signalling

• DOI: 10.1038/s41467-018-05794-1
• Publication Date: 2018-08-13T10:01:00Z
• Authors: Yanrui Jiang; Makiko Seimiya; Tommy Beat Schlumpf; Renato Paro
• Keywords: Signalling; Signalling pathways; Steroid hormone

Abstract Polycomb group proteins are epigenetic regulators maintaining transcriptional memory during cellular proliferation. In Drosophila larvae, malfunction of Polyhomeotic (Ph), a member the PRC1 silencing complex, results in neoplastic growth. Here, we report an intrinsic tumour suppression mechanism mediated by steroid hormone ecdysone metamorphosis. Ecdysone alters growth into nontumorigenic state mutant ph cells which then become eliminated adult stage. We demonstrate that exerts this function inducing heterochronic network encompassing activation microRNA lethal-7 , suppresses its target gene chronologically inappropriate morphogenesis . This pathway can also promote remission brain tumours formed mutants, revealing restraining different types. Given conserved role let-7 identification and molecular characterization innate eviction flies might provide important clues towards exploitation related pathways for human therapy.