Parvalbumin+ interneurons obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit in dentate gyrus

• DOI: 10.1038/s41467-018-06899-3
• Publication Date: 2018-10-29T15:49:41Z
• Authors: Claudia Espinoza; Segundo Jose Guzman; Xiaomin Zhang; Peter Jonas
• Keywords: Interneuron

Abstract Parvalbumin-positive (PV + ) GABAergic interneurons in hippocampal microcircuits are thought to play a key role several higher network functions, such as feedforward and feedback inhibition, oscillations, pattern separation. Fast lateral inhibition mediated by may implement winner-takes-all mechanism the input layer. However, it is not clear whether functional connectivity rules of granule cells (GCs) dentate gyrus consistent with mechanism. Using simultaneous patch-clamp recordings from up seven GCs four PV gyrus, we find that structured space, synapse-specific, enriched specific disynaptic motifs. In contrast neocortex, (in which GC inhibits neighboring via interneuron) ~ 10-times more abundant than recurrent itself). Thus, unique enable perform higher-order computations.