Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential

• DOI: 10.1038/s41467-018-07631-x
• Publication Date: 2018-11-26T10:53:10Z
• Authors: Linda Wampach; Anna Heintz-Buschart; Joëlle V. Fritz; Javier Ramiro-Garcia; Janine Habier; Malte Herold; Shaman Narayanasamy; Anne Kaysen; Angela H. Hogan; Lutz Bindl; Jean Bottu; Rashi Halder; Conny Sjöqvist; Patrick May; Anders F. Andersson; Carine de Beaufort; Paul Wilmes
• Keywords: Priming (agriculture)

Abstract The rate of caesarean section delivery (CSD) is increasing worldwide. It remains unclear whether disruption mother-to-neonate transmission microbiota through CSD occurs and it affects human physiology. Here we perform metagenomic analysis earliest gut microbial community structures functions. We identify differences in encoded functions between microbiomes vaginally delivered (VD) neonates. Several functional pathways are over-represented VD neonates, including lipopolysaccharide (LPS) biosynthesis. link these enriched to individual-specific strains, which transmitted from mothers neonates case VD. stimulation primary immune cells with LPS isolated early stool samples results higher levels tumour necrosis factor (TNF-α) interleukin 18 (IL-18). Accordingly, the observed TNF-α IL-18 neonatal blood plasma after Taken together, our support that disrupts specific linked repertoires immune-stimulatory potential during a critical window for system priming.