Ultrasensitive detection of miRNA with an antimonene-based surface plasmon resonance sensor

• DOI: 10.1038/s41467-018-07947-8
• Publication Date: 2018-12-28T11:43:18Z
• Authors: Tianyu Xue; Weiyuan Liang; Yawen Li; Yuanhui Sun; Yuanjiang Xiang; Yupeng Zhang; Zhigao Dai; Yanhong Duo; Leiming Wu; Kun Qi; Bannur Nanjunda S...; Lijun Zhang; Xiaoqiang Cui; Han Zhang; Qiaoliang Bao
• Keywords: Antimony; Science; Q; DNA, Single-Stranded; Biosensing Techniques; Surface Plasmon Resonance; Sensitivity and Specificity; 01 natural sciences; Article; Nanostructures; 0104 chemical sciences; MicroRNAs; Limit of Detection; Lab-On-A-Chip Devices; Neoplasms; Biomarkers, Tumor; Humans; Graphite

MicroRNA exhibits differential expression levels in cancer and can affect cellular transformation, carcinogenesis metastasis. Although fluorescence techniques using dye molecule labels have been studied, label-free molecular-level quantification of miRNA is extremely challenging. We developed a surface plasmon resonance sensor based on two-dimensional nanomaterial antimonene for the specific detection clinically relevant biomarkers such as miRNA-21 miRNA-155. First-principles energetic calculations reveal that has substantially stronger interaction with ssDNA than graphene previously used DNA sensing, due to thanking more delocalized 5s/5p orbitals antimonene. The limit reach 10 aM, which 2.3-10,000 times higher those existing sensors. combination not-attempted-before exotic sensing material SPR architecture represents an approach unlocking ultrasensitive provides promising avenue early diagnosis, staging, monitoring cancer.