RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family

• DOI: 10.1038/s41467-018-08035-7
• Publication Date: 2019-01-02T14:30:32Z
• Authors: Young-Ok Son; Hyo-Eun Kim; Wan-Su Choi; Churl-Hong Chun; Jang-Soo Chun
• Keywords: Pathogenesis

Osteoarthritis (OA) is a whole-joint disease characterized by cartilage destruction and other pathological changes. There currently no effective disease-modifying therapy. Here we investigate the post-transcriptional mRNA regulation of OA-modulating proteins in chondrocytes show that ZFP36 family member, ZFP36L1, specifically upregulated OA humans mice. Adenovirus-mediated overexpression ZFP36L1 alone mouse knee-joint tissue does not modulate pathogenesis. However, genetic ablation or silencing Zfp36l1 significantly abrogates experimental Knockdown increases expression two heat shock protein 70 (HSP70) members, which act as its direct targets. Furthermore, HSPA1A joint tissues protects mice against inhibiting chondrocyte apoptosis. Our results indicate RNA-binding protein, regulates HSP70 members appear to protect pathogenesis