The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope

• DOI: 10.1038/s41467-019-08437-1
• Publication Date: 2019-02-04T11:04:09Z
• Authors: Yan Wang; Yanyan Chen; Juan Chen; Lijun Wang; Leitong Nie; Juanjuan Long; Haishuang Chang; Jian Wu; Chenhui Huang; Ming Lei
• Keywords: Synapsis; Synaptonemal complex; Nuclear pore; Telomere-binding protein

Abstract During meiotic prophase I, telomeres attach to and move on the nuclear envelope (NE), regulating chromosome movement promote homologous pairing. Meiosis-specific proteins TERB1, TERB2 MAJIN play a key role in this process. Here, we report crystal structures of human TERB1-TERB2 TERB2-MAJIN subcomplexes. Specific disruption or interaction mouse Terb2 gene abolishes telomere attachment NE causes aberrant pairing disordered synapsis. In addition, depletion SUN1 also partially disrupts telomere-NE connection. We propose that telomere-TRF1-TERB1-TERB2-MAJIN-NE network telomere-LINC complex connection are likely two separate but cooperative pathways stably recruit meiosis I. Our work provides molecular model between reveals correlation synapsis defective NE.