Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage

• DOI: 10.1038/s41467-019-08853-3
• Publication Date: 2019-03-08T11:03:45Z
• Authors: Rene S. Hendriksen; Patrick Munk; Patrick Njage; Bram van Bunnik; Luke McNally; Oksana Lukjancenko; Timo Röder; David Nieuwenhuijse; Susanne Karlsmose...; Jette Kjeldgaard; Rolf S. Kaas; Philip Thomas Lan...; Josef Korbinian Vogt; Pimlapas Leekitch...; Milou G. M. van d...; Tina Zuidema; Ana Maria de Roda...; Simon Rasmussen; Bent Petersen; ; Artan Bego; Catherine Rees; Susan Cassar; Kris Coventry; Peter Collignon; Franz Allerberger; Teddie O. Rahube; Guilherme Oliveira; Ivan Ivanov; Yith Vuthy; Thet Sopheak; Christopher K. Yost; Changwen Ke; Huanying Zheng; Li Baisheng; Xiaoyang Jiao; Pilar Donado-Godoy; Kalpy Julien Coul...; Matijana Jergović; Jasna Hrenovic; Renáta Karpíšková; Jose Eduardo Vill...; Mengistu Legesse; Tadesse Eguale; Annamari Heikinheimo; Lile Malania; Andreas Nitsche; Annika Brinkmann; Courage Kosi Sets...; Bela Kocsis; Norbert Solymosi; Thorunn R. Thorst...; Abdulla Mohamed H...; Masoud Alebouyeh; Dearbhaile Morris; Martin Cormican; Louise O’Connor; Jacob Moran-Gilad; Patricia Alba; Antonio Battisti; Zeinegul Shakenova; Ciira Kiiyukia; Eric Ng’eno; Lul Raka; Jeļena Avsejenko; Aivars Bērziņš; Vadims Bartkevics; Christian Penny; Heraa Rajandas; Sivachandran Pari...; Malcolm Vella Haber; Pushkar Pal; Gert-Jan Jeunen; Neil Gemmell; Kayode Fashae; Rune Holmstad; Rumina Hasan; Sadia Shakoor; Maria Luz Zamudio...; Dariusz Wasyl; Golubinka Bosevska; Mihail Kochubovski; Cojocaru Radu; Amy Gassama; Vladimir Radosavl...; Stefan Wuertz; Rogelio Zuniga-Mo...; Moon Y. F. Tay; Dagmar Gavačová; Katarina Pastuchova; Peter Truska; Marija Trkov; Kerneels Esterhuyse; Karen Keddy; Marta Cerdà-Cuéllar; Sujatha Pathirage; Leif Norrgren; Stefan Örn; D. G. Joakim Larsson; Tanja Van der Hei...; Happiness Houka K...; Bakary Sanneh; Pawou Bidjada; Berthe-Marie Njan...; Somtinda Christel...; Belkis Levent; John Scott Meschke; Nicola Koren Beck; Chinh Dang Van; Nguyen Do Phuc; Doan Minh Nguyen ...; Geoffrey Kwenda; Djim-adjim Tabo; Astrid Louise Wester; Sara Cuadros-Orel...; Clara Amid; Guy Cochrane; Thomas Sicheritz-...; Heike Schmitt; Jorge Raul Matheu...; Awa Aidara-Kane; Sünje J. Pamp; Ole Lund; Tine Hald; Mark Woolhouse; Marion P. Koopmans; Håkan Vigre; Thomas Nordahl Pe...; Frank M. Aarestrup
• Keywords: Resistome

Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations difficult. Here, we use metagenomic analysis of untreated sewage characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences abundance and diversity genes between Europe/North-America/Oceania Africa/Asia/South-America. taxonomy only explains minor part variation that observe. no evidence cross-selection antimicrobial classes, or effect air travel sites. However, gene strongly correlates with socio-economic, health environmental factors, which predict abundances all countries world. Our findings suggest vary by region, improving sanitation could potentially limit burden AMR. propose as an ethically acceptable economically feasible approach continuous surveillance prediction