SWITCH 1/DYAD is a WINGS APART-LIKE antagonist that maintains sister chromatid cohesion in meiosis

• DOI: 10.1038/s41467-019-09759-w
• Publication Date: 2019-04-15T10:02:52Z
• Authors: Chao Yang; Yuki Hamamura; Kostika Sofroni; Franziska Böwer; Sara Christina St...; Hirofumi Nakagami; Arp Schnittger
• Keywords: Separase

Abstract Mitosis and meiosis both rely on cohesin, which embraces the sister chromatids plays a crucial role for faithful distribution of chromosomes to daughter cells. Prior cleavage by Separase at anaphase onset, cohesin is largely removed from non-proteolytic action WINGS APART-LIKE (WAPL), mechanism referred as prophase pathway. To prevent premature loss chromatid cohesion, WAPL inhibited in early mitosis Sororin. However, Sororin homologs have only been found function inhibitors during vertebrates Drosophila . Here we show that SWITCH 1/DYAD defines antagonist acts Arabidopsis Crucially, SWI1 becomes dispensable cohesion absence Despite lack any sequence similarities, regulated functions similar manner hence likely representing case convergent molecular evolution across eukaryotic kingdom.