STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus

• DOI: 10.1038/s41467-019-10863-0
• Publication Date: 2019-06-27T10:02:45Z
• Authors: Pia-Katharina Teg...; Julia Spanier; Katharina Borst; Jennifer Becker; André Riedl; Christoph Hirche; Luca Ghita; Jennifer Skerra; Kira Baumann; Stefan Lienenklaus; Marius Doering; Zsolt Ruzsics; Ulrich Kalinke
• Keywords: Sting; Cytomegalovirus; Interferon type I; Permissiveness

Abstract Cytomegalovirus is a DNA-encoded β-herpesvirus that induces STING-dependent type 1 interferon responses in macrophages and uses myeloid cells as vehicle for dissemination. Here we report STING knockout mice are resistant to murine cytomegalovirus (MCMV) infection wild-type controls, whereas with combined Toll-like receptor/RIG-I-like receptor/STING signaling deficiency do not mount succumb the infection. Although alone dispensable survival, early IFN-β induction Kupffer controls hepatic virus propagation. Infection experiments an inducible reporter MCMV show constrains replication limits viral dissemination via these cells. By contrast, restriction of from hepatocytes other organs independent STING. Thus, during involved cells, it survival.