Renewed proliferation in adult mouse cochlea and regeneration of hair cells

• DOI: 10.1038/s41467-019-13157-7
• Publication Date: 2019-12-04T11:03:29Z
• Authors: Yilai Shu; Wenyan Li; Mingqian Huang; Yi-Zhou Quan; Deborah Scheffer; Chunjie Tian; Yong Tao; Xuezhong Liu; Konrad Hochedlinger; Artur A. Indzhyku...; Zhengmin Wang; Huawei Li; Zheng-Yi Chen
• Keywords: Spiral ganglion; Reprogramming

Abstract The adult mammalian inner ear lacks the capacity to divide or regenerate. Damage generally leads permanent hearing loss in humans. Here, we present that reprogramming of induces renewed proliferation and regeneration cell types. Co-activation cycle activator Myc progenitor gene Notch1 robust diverse cochlear sensory epithelial Transient MYC NOTCH activities enable supporting cells respond transcription factor Atoh1 efficiently transdifferentiate into hair cell-like cells. Furthermore, uncover mTOR pathway participates MYC/NOTCH-mediated regeneration. These regenerated take up styryl dye FM1-43 are likely form connections with spiral ganglion neurons, co-activation is sufficient reprogram fully mature proliferate regenerate auditory organs.